Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior
نویسندگان
چکیده
منابع مشابه
Rapid-Fire Synaptic Vesicle Exocytosis
2ϩ-mediated regula-appears to be a requisite refractory period of at least tion of PIP 2 metabolism, Hardie et al. estimate that a 20 ms between fusion of one vesicle and the next at a single photon of light might deplete all of the PIP 2 in four single release site (Stevens and Wang, 1995), with a microvilli rather than the PIP 2 in the immediate vicinity of maximum rate of 15–30 fusion events...
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At the heart of synaptic transmission resides the synaptic vesicle cycle – a membrane trafficking pathway in which small membrane-bound vesicles mediate the release of neurotransmitter from presynaptic terminals. The cycle resembles general membrane trafficking and has three phases: vesicle filling, release and recycling. During filling, neurotransmitter is loaded into vesicles via vesicular ne...
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The recent identification of novel proteins associated with the membranes of synaptic vesicles has ignited the field of molecular neurobiology to probe the function of these molecules. Evidence is mounting that the vesicle proteins vamp (synaptobrevin), rab3A, synaptophysin, synaptotagmin (p65) and SV2 play an important role in regulated exocytosis, by regulating neurotransmitter uptake, vesicl...
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In this issue of Neuron, Voglmaier et al. provide new evidence that the retrieval of synaptic vesicle transporters after exocytosis proceeds along at least two different endocytic pathways. This work provides new insight into the mechanisms of sorting synaptic vesicle cargo at the cell surface.
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2007
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7601737